The Foolproof plan to Lower Blood Pressure

What to Do About Lower Blood Pressure

Medication is not really the only means to diminish your blood pressure. Magnesium is famous for it’s all-around relaxing impact on your body. It can be quite variable, even in the same person.

To lower and control blood circulation pressure, many people take a couple of medicines. Additionally, there is good news. A higher degree of sodium is famous to raise blood pressure.

In the same way, an eating plan which is too reduced in potassium can create your body accumulate an excessive amount of sodium. It really is found in the treating elevated cholesterol levels, higher blood circulation pressure and arteriosclerosis. Potassium is a mineral with a positive impact on lowering blood pressure levels naturally and also you would like to consume at least 4700 mg a day. For more accurate readings use blood pressure calculator by age.

Just in case the blood pressure shows drastic adjustments, then it is confirmed that the individual suffers from this condition. it really is a proper problem, especially with all the stresses of modern life. It aids in lowering both systolic together with diastolic blood pressure levels.

Many have a short-term raise in blood circulation pressure if they’re under stress. Blood sugar will rise as well. The automatic development in tension a lot of people experience once they’re being scrutinized contributes to artificially higher blood circulation pressure readings. lots of people now elect for more natural approaches for controlling high blood pressure.

The History of Lower Blood Pressure Refuted

Besides shedding pounds, in addition, you had better maintain your eye in your waistline. In little quantities, it could possibly lessen your blood circulation pressure by 2 to 4 millimeter Hg. Losing a maximum of ten pounds can help you decrease your blood pressure naturally and if you’re obese your have to shed weight is a lot more urgent.

Standard consumption will help lower weight dramatically. You need to try and restrict the total amount of sodium which you eat. Even just a little decline in the use of sodium might help to lower your blood pressure levels levels by as much as 2 to 8 mm of mercury.

The Upside to Lower Blood Pressure

You have to buy the food grade. This means they have stretched back also.

The Downside Risk of Lower Blood Pressure

Simply speaking, when our anatomical bodies are inside this state, it might be the explanation for raised blood pressure, heart disease, and plenty of other diseases. Reducing your blood cholesterol level has transformed into the effective ways it is possible to lower your possibility of coronary disease. if you’re trying to find an inexpensive alternative all-natural wellness care for depression, think about the Water Cures protocol.

Constantly elevated quantities of blood pressure or hypertension raises the chance for a number of different ailments, and requirements attention. It could lift your blood circulation pressure and with time, may enhance the permanent state of hypertension. Most often when the specific supply of hypertension isn’t clear, it really is referred to as essential hypertension.

Definitions of Lower Blood Pressure

You don’t have to completely quit eating fried foods, but you have to control the need to binge. If eating full-fat dairy isn’t an option for your needs, you sometimes use the vitamin for a supplement. it will cause you to feel much better.

It was observed that the chief reason behind hypertension in people is they just do not stay glued to a healthful and nutritious diet system. Therefore, it might be more straightforward to stop smoking and lower the intake of alcohol. Variations in gut flora from 1 person to some other seemingly have a big impact on whether it is the actual situation that you develop coronary disease.

Oahu is the intent behind good clinical practice to reduce elevated quantities of pressure wherever possible to help you to cut back the risk of complications like heart attack and stroke. Do not let it happens, since it could cause multiorgan damage including heart and kidney damage. for those who haven’t experienced this frustrating and frequently painful condition, it could be difficult to understand the amount of pain which may radiate from such a relatively little location.

It promotes normal cell rise and development. The greatest methods of them are dietary modifications, weight control, and physical activity. So as to introduce a pure formula for blood pressure levels control, a report will have to see perhaps the formula worked.

The Tried and True Method for Lower Blood Pressure in Step by Step Detail

If you want to understand how to control blood pressure levels, you need to know where to receive most of the available medication. There are no actual medicines to heal stress. there are certain different kinds of blood pressure levels medications.

It is possible for you to take pleasure in these healthier yellow peppers breaded and fried. If you wish to be familiar with features of apple cider vinegar to reduce blood pressure levels, you should know simple tips to consume the vinegar also. It generates a delightful digestive aid and assists to lessen excess fluid.

Furthermore, you ought to be working together with a practical wellness practitioner to greatly help lead you through these strategies. You raise a good question! It’s not necessary to truly feel guilty, the good thing is that the issue is really beneath your control!

The New Fuss About Lower Blood Pressure

Unwanted effects are rare and simply happen in just a little amount of people. These changes are worthwhile simply because they may save your life. Once you make time and energy to get this done, you reduce stress.

In case you have a household reputation for hypertension it’s a lot more required for you to earn lifestyle changes. Or it might be since it is frequently a lot calmer for a female to keep on creating her family with similar man. It’s often referred to as king of vegetables” due to its pungent taste.

Septum piercing pain

Nose piercings don’t typically leave scars. Septum piercing pain can occur, if your piercing is not done by professional. They have become increasingly popular among young women as well as men. Nose piercing is valuable to a great deal of cultures. Nose piercings, generally, involve piercing of the skin in addition to the cartilage of any area of the nose. Nose piercing is the most recent fashion trend. Nose piercings are really popular around the world. They can surely enhance the way you look, but you have to take care to avoid the dangers of piercing your nose.

Does septum piercing cause any pain?

Piercings are really popular nowadays. Should you decide to earn bridge piercing, you’d better figure out the in depth details about it and all the potential risks. It is among the oldest kinds of piercings around. Facial piercings are a simple way of creating a style statement. Facial piercings for guys are now increasingly common in the past few decades. Septum piercing does not cause any pain. In fact, septum piercing pain Is very rare, and even more so when done professionally. Septum piercing pain can include inflammation and repetitive pain. With proper approach all this can be avoided. Septum piercing pain will go away in 3 months from your procedure.

Body piercing is a significant fashion statement nowadays. Septum piercing has changed into a trending culture on earth of piercings. Septum piercing needs to be accomplished by a specialist. In case you suffer from diabetes and high blood sugar levels refer to this article.

In fact, it is among the least painful piercings you are able to get, for a wonderful piercer won’t actually go through the cartilage. The genuine piercing is fixed within the center portion of the nose, the very small tissue underneath the cartilage. It is the sole piercing that may be hidden. Unique piercings have unique healing periods. Some individuals also acquire anal piercings that can be painful and difficult to take care of. This piercing is typically done with the assistance of a straight barbell, which includes a straight bar which has a small bead on every end. Industrial Piercing has gotten very popular today among both women and men.

It’s mandatory that you ask the piercer about the length of time you’ll need to wait to modify your stud. The piercer ought to be well-trained. You’d like to pick a piercer that operates beneath sanitary troubles. Sometimes, the piercer will have the ability to counsel you on the appropriate things to do to heal the infection. Even though some piercers could just pierce both holes at the exact same session. Whatever kind you opt to get, be sure that you’d be consulting with your body piercer regarding how you can look after the new nose piercing even before you’ve got your nose pierce. One ought to only visit an expert body piercer who has good expertise inside this area.

Make certain you aren’t allergic to the metal which is being used for the piercing. The cartilage wall between both nostrils is known as Nasal Septum. It is essentially a surface piercing, and hence, differs from both of the other forms of nose piercings.

The labret stud used for piercing, is generally longer than that which you want, which actually eases the procedure for swelling. Nose rings are now increasingly popular throughout the last few decades. Captive bead rings are rather popular too.

Piercing the skin rather than the cartilage can greatly minimize the pain, in addition to other discomforts related to this form of piercing. When you decide to have a septum piercing, you are certain to be surprised about the immense number of jewelry that’s available. Hematoma denotes the accumulation of blood in an organ, muscles, or under the top layer of the skin. It dissolves the pus in the bump, and gives the much-needed relief.

In the event the scar does not leave, you’ll need to receive it surgically removed. The very first point to be thought about is whether there’s enough skin on the bridge space to find the piercing done. It may involve the top or lower lip. Just as with any other sort of piercing, taking great aftercare of your nose piercing by following the necessary nose piercing care instructions is most important so you can appreciate your piercing for quite a long moment. Nevertheless, you have to realize that a nose piercing done badly may lead to infections which may cause more health issues. Today, nose piercing is among the most popular kind of body piercing. Consequently, it is critical that folks know about the appropriate nose piercing aftercare.

The wound generally starts to heal right after the procedure. The bleeding is normally observed only as long as the status is severe. It will usually stop within 24 hours, while the discharge may last for several days or weeks.

You might have an infection. In the event the infection looks serious in nature, then consider to spend the aid of an expert. Piercing infections are sometimes not harmful.

Proper diabetes education

Diabetes Education – Read about Diabetes Education presented in simple easy to understand language

Diabetes is now increasingly being recognized as a major threat to the world. In fact, the 19th World Diabetes Congress which was held in Cape Town made an announcement that that by the year 2025, diabetes would affect around 6% of the world’s population. This works out to about 240 million people out of which 80% would be from the developing countries. As of today, the annual death toll due to diabetes is an alarming 6% of the world’s population.

Refer to sugar and glucose levels chart for additional information. Make sure you visit the fat burning heart rate calculator as well in order to find out which is your proper heart rate zone in which you should exercise in case you have diabetes.

In the light of all these alarming facts and prognostications, there are a lot of awareness campaigns and education programs which have been striving to educate people about the dangers of diabetes due to poor diet and lifestyles and also as act a support system for those who are already suffering from this disease. These organizations are also trying to push the health authorities to take some initiative in the prevention of diabetes among the public as well as assist the in the education programmes.

Keywords: blood sugar levels chart, blood glucose chart, heart rate, heart rate zones calculator

Blood sugar levels chart and Normal blood sugar levels in women

Blood sugar levels chart and Normal blood sugar levels in women

Insulin controls the amount of glucose or sugar in the blood and the rate at which it is absorbed by the body’s cells for energy. If a woman blood glucose levels are high or low, can lead to health problems. Always monitor your blood sugar levels by using blood sugar levels chart.

Blood sugar levels chart is useable in all situations.

In diabetes, the blood sugar levels are higher than normal. 15.7 million Americans have diabetes by the American Diabetes Association. It is the sixth leading cause of death in the United States.

Hypoglycemia

In hypoglycaemic women blood glucose levels are below normal, hunger, dizziness, sweating, confusion, palpitations and tingling caused the lips.

Blood sugar levels

Creatine level extremely low as well as triglycerides.

My latest A1c was 5.7 on 6-11-14 but I work at that. Simple sugars and starches are burned up so fast that the slightest exercise would make them of little value. A simple candy bar works at the core level of insulin to make the blood sugar rise faster than any other means.

Keywords: blood sugar, blood sugar levels chart, blood sugar chart, diabetes, glucose, blood glocuse

Juice, soda, milk and glucose tablets work for less than an hour at best. 95% of people don’t add back the fiber, sugar and starches when looking at carbs. Most grown food has from 78 to 82% starch per gram of carbohydrate.

I have eaten a 468 carb meal using this method, taken 85 units of Humalog and gotten a two hour blood glucose reading. Depending on the residual value of the sugars in complex carbs like sourdough bread blood sugar later can either depress or spike. I have had low creatine levels before and had many episodes of hypoglycemia until I got the correct dosage of Humalog right then no more oral anti-diabetic drugs ever.

There’s more to that

Blood sugar level is measured in milligrams of glucose per liter of blood tenth. In women, normal blood glucose levels are 110 mg / dL and younger. Borderline blood glucose levels, impaired glucose intolerance, considered are of 110 to 126 mg / dl. In women with diabetes blood sugar levels remain higher than 126 mg / dl for two to three days.

How to properly measure blood sugar

Women can blood sugar levels at home test with glucose test strips. Electronic test equipment available.

Solutions

A low-fat, high-fibre diet and regular exercise can help promote normal blood sugar levels in women. Drugs or insulin therapies are also available. Diabetes affects more than 8 percent of the American population. This is definitely a staggering statistic, given that the number of deaths due to complications from diabetes is also high. Typically, diabetes is a disease that lasts an entire lifetime because there is no medical cure for it. Usually, patients take medication (or insulin injections) to prevent potentially fatal complications.

Diabetes is a condition that results from the presence of high blood sugar in the blood stream. This can be brought on by two factors – the first is if the body cannot efficiently utilize insulin and the second factor is when the body cannot produce sufficient amounts of insulin.

Insulin is a substance produced in the body that helps to move glucose from the bloodstream to the cells that need it. Cells use glucose to produce energy, among other things. Therefore, it’s easy to see why a lack of insulin can lead to potentially serious complications.

There are two types of diabetes: type 1 and type 2 diabetes.

Type 1 diabetes is the rare one and makes up only 10 percent of all diabetes cases. This is where the body totally fails to produce insulin and the condition typically develops during teenage years. When you have this type of diabetes and decide to take the medical solution, you’d need to get insulin injections throughout the remainder of your life. In addition, patients with type 1 diabetes have to follow a strict diet plan and have to carry out regular blood tests to monitor glucose levels in blood.

Keywords: blood sugar, blood sugar levels chart, blood sugar chart, diabetes, glucose, blood glocuse

How to achieve normal blood sugar level?

Normal blood sugar level

Insulin controls the amount of glucose or sugar in the blood and the rate at which it is absorbed by the body’s cells for energy. If blood glucose levels are high or low, this may lead to health problems.

In diabetes, the blood sugar levels are higher than normal. 15.7 million Americans have diabetes as stated so by the American Diabetes Association. It is the sixth leading cause of death in the United States. Read more about normal blood sugar level.

Hypoglycemia

In hypoglycemic women blood glucose levels are below normal, hunger, dizziness, sweating, confusion, palpitations and tingling caused the lips.
Blood sugar levels

Blood sugar level is measured in milligrams of glucose per liter of blood. In women, normal blood glucose levels are 110 mg / dL and less. Borderline blood sugar levels, impaired glucose intolerance, is considered when a person has 110 to 126 mg / dl values measured. In women with diabetes blood sugar level remains higher than 126 mg / dl for two to three days.

How to measure blood sugar level?

Women can test their blood sugar levels at home with glucose test strips. Electronic test equipment is also available and not too expensive.

Solutions

A low-fat, high-fiber diet and regular exercise can help promote normal blood sugar level in women. Drugs or insulin therapies are also available.

What is normal blood sugar level?

For people not diagnosed with diabetes a normal blood sugar level is 4-6mmol/l on an empty stomach. If you are diagnosed with diabetes these numbers will be hard to reach without the intervention of injected insulin, or without following a strict diet.

Normal blood sugar level for adult is as follows below.

A normal blood sugar level is anything in between 72 mg/dL and 108 mg/dL (4 to 6 mmol/L) for a healthy person. For children up to 6 years of age normal blood sugar level before eating is between 100 mg/dL (5.5 mmol/L) and 180 mg/dL (10 mmol/L). Before sleep values should be between 110 mg/dL (6.1 mmol/L) and 200 mg/dL (11.1 mmol/L). For children between the age of 6 and 12, before eating, normal blood sugar level should be between 90 mg/dL (5 mmol/L) and 180 mg/dL (10 mmol/L). Before sleep values should be between 100 mg/dL (5.5 mmol/L) and 180 mg/dL (10 mmol/L).

Units of measure for normal blood sugar level

The blood glucose levels can be divided into two units specify: “milligrams per deciliter” (mg/dl) or “millimoles per liter” (mmol/l). In a healthy person the normal blood sugar level varies slightly. In the fasting state, it should be less than 100 mg / dl (5.6 mmol / l). After a meal, the value should still remain lower than 140 mg/dl (7.8 mmol / l).

Goal of diabetes therapy is to approach these standard values (also referred to as normal blood sugar level) ​​and the natural course of blood glucose levels and to avoid particularly high values ​​after meals. Such short-term spikes in blood sugar induce the development of vascular lesions such as arteriosclerosis. On the other hand, the blood sugar levels may not be as lowered fast as this puts a patient in danger of experiencing hypoglycaemia. If you are diagnosed with diabetes (either type 1 or type 2) always ensure that you are in control of your blood sugar levels. Keeping a normal blood sugar level is not only healthy but is also mandatory as well. Normal blood sugar level is the ground zero for every diabetic.

The long-term blood sugar HbA1c

Because when measuring blood sugar level we always take a snapshot of current values the so-called HbA1c test was introduced. Your doctor will measure your blood sugar level every three months to determine your average blood sugar levels and comparing it to normal blood sugar level. This is also known as “long-term value” or “blood sugar memory”. The HbA1c value indicates how many glucose molecules have docked with the red blood cells – the higher the blood sugar levels the more did so. Since red blood cells have a life span of about 120 days, the HbA1c average blood sugar level is an reflection of your values over the last eight to twelve weeks. This is critical process when assessing your values and comparing it to normal blood sugar level.

normal blood sugar level in patients

The HbA1c can be specified in units of percent and millimoles per mol (mmol / mol).
In people without diabetes, the HbA1c is around 30 mmol / mol (5 percent).

HbA1c: Individual target values

In type 1 diabetes, the Diabetes Association recommends an HbA1c level below 58 mmol / mol (7.5 percent), if there is no direct danger of hypoglycemia or other side effects. In type 2 diabetes, targets are set as 48-58 mmol / mol (6.5 to 7.5 percent). Normal blood sugar level standard stays the same – normal blood sugar level should be somewhere in between 72 mg/dL and 108 mg/dL (4 to 6 mmol/L),

The said target values ​​of blood sugar are recommended values ​​and not binding limits that must be achieved at all costs.

Normal blood sugar level chart

The blood glucose level (plasma glucose value) can be determined by 2 methods. These are: fasting plasma glucose (FPG): from capillary whole blood after a fasting period of at least 8 hours or oral glucose tolerance test (according to WHO guidelines): 3 days prior to the test at least 150-200 grams of carbohydrate per day for normal physical activity out, after 10-16 hours of fasting at 8am determine the fasting blood glucose and after the patient 75 g glucose dissolved in 250-300 ml of water, to drink within 5 minutes, -> measure blood sugar after 2 hours again.

In primary care area of ​​blood glucose is most often measured as fasting blood glucose value over blood glucose test strip or the laboratory. Unless you know your blood glucose levels, you can see from the following table below which is normal blood sugar level.

These are as follows.

NORMAL BLOOD SUGAR LEVEL

  • Normal value Impaired glucose tolerance 100-125 mg / dl (5.6 to 6.9 mmol / l)
  • diabetes from 126 mg / dl (From 7.0 mmol / l)
  • oral glucose tolerance test after 2 hours
  • normal blood sugar level value as impaired glucose tolerance 140-199 mg / dl (7.7 to 11.0 mmol / l)
  • diabetes from 200 mg / dl (From 11.1 mmol / l)

Blood glucose values ​​show during the day as strong fluctuations, depending on the physical activity, food intake and overall health of an individual. A routinely collected, increased blood glucose value can therefore mean the diabetes diagnosis, suggestive of impaired glucose tolerance (eg Type II diabetes), or just be a result of a meal. Normal blood sugar level stays marginal.

Therefore, the WHO recommends the diagnosis as follows:
A diabetes disease occurs when a presence of classical symptoms of diabetes, including: polyuria (increased urine volume), polydipsia (increased thirst), unexplained weight loss and at the same time a glucose level of above 200 mg / dl at any time of the day, regardless of the last meal ingestion is given. Furthermore, fasting plasma glucose 126 mg / dl, or the oral glucose tolerance test, the 2-hour value above 200 mg / dl, and a confirmation of the results by repeating measurements at a later time is done (unless clear signs of hyperglycemia are present).

All blood glucose values ​​are determined from the capillary whole blood or blood plasma. Therefore normal blood sugar level should be deemed after all above considerations are taken into account.

SUMMARY OF EXPLANATION
normal blood sugar level value: 70 – 100 mg / dl. This means that after at least 12 hours fasting (fasting blood glucose) are between 60 and 100 milligrams of glucose in a deciliter of blood.
normal blood sugar level and limit range: 101 – 130 mg / dl. From about 180 mg / dl, the so-called renal threshold is exceeded. The sugar can then be detected in the urine (urine test strips).
Diabetes = permanently increased blood sugar levels.
Diabetes Type I = happens mostly in young patients (juvenile diabetes). It happens when organism destroys its own antibodies (insulin dependent diabetes).
Type II diabetes (adult-onset) = Caused by the metabolic syndrome patients have an increasing insulin resistance. The cells in the tissue take too little insulin from the blood. The body tries to reduce sugar levels in the blood (blood sugar) by causing the pancreas to produce more insulin which could be fatal if not treated. This eventually leads to exhaustion of the pancreas, which in its turn adjusts the insulin production.

This post was tagged with keywords: diabetes, blood sugar level, normal blood sugar level chart, normal blood sugar level.

Natural Herbal Remedies and Supplements Guide for better Health and Blood Sugar Control

Are herbs really as healthy as people claim them to be?

Herbs are plants that have always been used to treat disease states. Knowledge about medicinal plants are continuously transmitted from generation to generation, while the latter is also continuously updated.
There’s more to herbs than needs the eye

It is true that a lot of knowledge of medicinal plants through generations also distorted and distorted. A lot more than the transfer of knowledge, I find it fascinating idea where some our ancestors acquired this knowledge and where to go is actually the beginnings of the use of medicinal plants. The latter answer will probably never get.

It is interesting to themselves the fact that folk medicine that is used for the treatment of medicinal plants, knowledge about them is not acquired in different laboratories, as we do today, the latter is obtained by using everyday use. Thus, sometimes the discovery of some medicinal properties also need a whole century. When using herbs to help the people from turning to nature, also occurred in various superstitions, the latter is most notably in the Middle Ages, but only in the treatment of medicinal plants throw a bad light.

Active substances in herbs

Among the superstitions can be found opinion on the fact that most of the active substances in plants of the new moon, it is necessary around the plants before they dig draw a circle that you should collect medicinal plants in the Midsummer Night, and much more. The latter are only beliefs and superstitions that have no fundamental or concrete bases that prove their authenticity. People eventually realized that the latter is nonsense and belief in superstitions was eventually supplanted common sense.
Our ancestors knew!

Despite the fact that our ancestors already thousands of years ago knew how much healing can plants provide, modern medicine will definitely need quite a few centuries to fully explore their function and meaning. All the efforts of scientists go towards the detection levels of medicinal plants, which could contribute to the improvement of existing drugs.

It is interesting to be able to adhere to medicinal plants, without any synthetic or any chemical ingredients and additives do wonders. You could say that it is the nature of our best doctor.

For medicinal plants are considered to be even today in many places the only domestic medicine and constitute the so-called local pharmacy. People still appreciate herbs that loves many drug effectively eliminate the symptoms of the disease and help people recover faster. It is also true that in recent years due to the significant progress made by the pharmaceutical industry interest in medicinal plants somewhat died.

There are many children and adolescents who do not know even the basic herbs, let alone to be educated about their operation and use. Also, due to the latter, I believe that our system should take a step forward and to educate young people about harmony with nature and the latter is what we offer. I’m sure people would be much healthier in so far as in his life include medicinal plants, especially if they were familiar with their proper use. See more.

On the books and manuals on medicinal plants has been gathering dust in many places and it would be helpful to remove the latter, read them, you via the internet and lectures gain knowledge and medicinal plants that return value for which the experiences and findings of science, we know that you actually have.

Home »Aurora planet” is intended not only the presentation of medicinal plants, but also their use. We must be aware that it takes all the medicinal plants accumulate carefully, at the same time protecting nature, you appreciate and collect only those plants that you actually know. Listen to nature and allow her to show us all their wealth, which is reflected in thousands of a variety of shades.

A breaking point in diabetic’s life

Diabetes is not one of those “Get it & forget it” Diseases (although what chronic disease is.) You never forget the day you were diagnosed (Christmas Eve is even more memorable for me now than before life with Diabetes) and you never forget those moments or events that never let you forget that Diabetes is part of your life.

Low blood sugar levels

I will have to say, of all the blogs that I have read and the scary experiences I have heard the tales of, the most consistent variable in all of them is low blood sugar. Blood pressure is also an important factor.

Low blood sugars seem to have the strongest mark on these stories. The thing that amazes me the most when I read and hear these stories is what was their blood sugar breaking point. What was that magic number that threw everything into a tailspin.

I guess what shocks and scares me the most is to hear how high these blood sugar reading are that completely convert the person into a state of “vegetation” for lack of a better word. I here of blood sugar readings in the 60’s and 50’s causing my fellow Diabetics unravel and/or to be unable to perform the most basic functions. When I read and hear about these stories, it makes me wonder, “why am I different?”.

You see, for me if I have a blood sugar in the 60’s I would be hard pressed to tell you if I was low unless I had tested and seen the reading. Even a number in the 50s gives me little to no worry because I could be working on 3 projects at work, talking on the phone and checking email without flinching.

diabetes

I may know that I am getting low but I know that I could grab a quick pick me up while juggling everything else and not miss a step. For me, I am not sure if this is something that I should be alarmed about or just fortunate that my range of ”functional blood sugar” is wider than many of my fellow Diabetics.

I really can’t say why I am so high functioning at lower blood sugars compared to others I read about but I do know it doesn’t scare me to have a blood sugar of 50 and that in itself is a little scary.

I don’t know if I, or anyone, will be able to answer this question for me and I guess I am not all that worried if I never know. I don’t know if being a high functioning Diabetic when it comes to low blood sugars has made me more accepting of my Diabetes. What I do know is that I will never let Diabetes dictate what I can do, can’t do or mold who I am. I am the one who is control.

Tags: Diabetes, hypoglycemia, low blood sugar, tolerance

Diabetes and chronic cellular stress

Diabetes, to my surprise, results from chronic cellular stress. The source of the stress is both legion and not really important to understanding what diabetes is. It all begins with the endoplasmic reticulum, an organelle inside every cell in our body.

The Endoplasmic Reticulum

The endoplasmic reticulum (ER) is an organelle in every cell in the body that is responsible for the folding, sorting and transport of proteins. On the surface of the ER are ribosomes that sequence amino acids into peptides and stuff the peptides through holes in the ER. Once inside the ER, chaperone proteins oversee the correct folding of the peptides into proteins, sometimes making small modifications to the peptides in the process.

If a peptide misfolds, the chaperones may help in refolding the protein or they may transport the misfolded protein to a location where it will be torn back down into its basic amino acids.

Physically, the ER looks like a series of boxes and tubes. It has been recently discovered that some of those tubes actually pass through the cell’s nucleus.

ER Stress

ER Stress, a sudden demand for increased protein production, occurs as a response to environmental situations such as wound healing. ER Stress is usually short lived and normal.

The Unfolded Protein Response

On the surface of the ER, sticking out like hairs, are strands of the protein ATF6a. If ER Stress occurs for an extended period of time or is severe, the ER may run low on chaperone proteins and unfolded peptides begin backing up in the ER. This condition is detected by the ER and produces the Unfolded Protein Response (UPR). UPR is simply the cleaving of ATF6a from the surface of the ER. Upon entering the nucleus of the cell, ATF6a causes the nucleus to call for increased production of chaperones; that is, it causes the genes for producing chaperones to be turned on.

I liken this to a factory that has more orders to do the final assembly work on proteins than it can handle. It requests from management more workers to fill the orders. In this case, the factory would also be manufacturing the additional workers, the chaperones.

Chronic ER Stress

When ER Stress occurs for protracted lengths of time, the ER starts running out of ATF6a; that is, the production of new chaperones decreases despite the continued need for them. This results in a cascade of events that result in the cell becoming increasingly insensitive to insulin. This is a protective response.

If you think of the factory analogy, this would be the case where the factory cannot obtain enough workers to keep up with the work load and the factory is filling up with unfinished product (unfolded proteins). The logical response at this point would be to slow down the arrival of peptides needing folding.

Because a cell’s response to insulin is not only the taking in of glucose but also the taking in of amino acids, insulin resistance slows the production by the ribosomes of peptides. That reduces ER Stress, but does not cure it unless the stressor that led to the state is removed. If the stressor is not removed, it will either be a holding action or a war lost.

Apoptosis

If the condition of the ER continues to degrade, once again the cell changes response. At this point the cell appears to its own apparatus to be irreparably damaged and orderly cell death (apoptosis) is initiated.

The Cure

Chronic ER Stress can result from innumerable environmental conditions – the internal environment of the body. Excessive glucose, lipids, toxins, chronic infections, and inflammatory cytokines are among the most common environmental conditions that lead to diabetes. Anything that requires the continuous, never-ending need to produce structural or secretory proteins will cause chronic ER Stress. This is why the “cause of diabetes” was so elusive.

To cure diabetes (and many other old age illnesses) it is necessary to reinforce, to actually grow, the ER so that it can handle the stress. At the same time, it is necessary to remove as many stressors as possible.